Endocrine Abstracts

Introduction: Klinefelter syndrome (KS) is the most common sex-chromosome disorder with a prevalence of 1 in every 660 men, but only 25% of the expected number of patients are diagnosed. It is also one of the most common endocrine disorders, and takes the third place after diabetes mellitus and thyroid gland diseases. KS is one of the most frequent causes of hypogonadism in men. It is known that hypogonadism in men has been found to be an independent risk factor for developmen...

Introduction: Underdiagnosis and delayed diagnosis of Klinefelter syndrome (KS) is a major problem. KS is revealed only in 25% of the expected amount of patients. Early diagnosis facilitates prevention of the long-term consequences of hypogonadism and permits to begin testosterone-replacement therapy opportunely. The ‘prototypic’ patient with KS has traditionally been described as tall, thin, with long hips, narrow shoulders, having gynecomastia, small testes, sparse...